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The Caenorhabditis elegans rhy-1 Gene Inhibits HIF-1 Hypoxia-Inducible Factor Activity in a Negative Feedback Loop That Does Not Include vhl-1
Hypoxia-inducible factor (HIF) transcription factors implement essential changes in gene expression that enable animals to adapt to low oxygen (hypoxia). The stability of the C. elegans HIF-1 protein is controlled by the evolutionarily conserved EGL-9/VHL-1 pathway for oxygen-dependent degradation....
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Copyright © 2006 by the Genetics Society of America
2006
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1667075/ https://ncbi.nlm.nih.gov/pubmed/16980385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.063594 |
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