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Two Distinct Roles for EGL-9 in the Regulation of HIF-1-Mediated Gene Expression in Caenorhabditis elegans

Oxygen is critically important to metazoan life, and the EGL-9/PHD enzymes are key regulators of hypoxia (low oxygen) response. When oxygen levels are high, the EGL-9/PHD proteins hydroxylate hypoxia-inducible factor (HIF) transcription factors. Once hydroxylated, HIFα subunits bind to von Hippel-Li...

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Bibliografske podrobnosti
Main Authors: Shao, Zhiyong, Zhang, Yi, Powell-Coffman, Jo Anne
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778979/
https://ncbi.nlm.nih.gov/pubmed/19737748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.109.107284
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