A Deletion at the Mouse Xist Gene Exposes Trans-effects That Alter the Heterochromatin of the Inactive X Chromosome and the Replication Time and DNA Stability of Both X Chromosomes

The inactive X chromosome of female mammals displays several properties of heterochromatin including late replication, histone H4 hypoacetylation, histone H3 hypomethylation at lysine-4, and methylated CpG islands. We show that cre-Lox-mediated excision of 21 kb from both Xist alleles in female mous...

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Main Authors: Diaz-Perez, Silvia V., Ferguson, David O., Wang, Chen, Csankovszki, Gyorgyi, Wang, Chengming, Tsai, Shih-Chang, Dutta, Devkanya, Perez, Vanessa, Kim, SunMin, Eller, C. Daniel, Salstrom, Jennifer, Ouyang, Yan, Teitell, Michael A., Kaltenboeck, Bernhard, Chess, Andrew, Huang, Sui, Marahrens, York
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright © 2006 by the Genetics Society of America 2006
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1667074/
https://ncbi.nlm.nih.gov/pubmed/16980402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.051375
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