Genetically modified anthrax lethal toxin safely delivers whole HIV protein antigens into the cytosol to induce T cell immunity

Bacillus anthrax lethal toxin can be engineered to deliver foreign proteins to the cytosol for antigen presentation to CD8 T cells. Vaccination with modified toxins carrying 8–9 amino acid peptide epitopes induces protective immunity in mice. To evaluate whether large protein antigens can be used wi...

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I whakaputaina i:	Proc Natl Acad Sci U S A
Ngā kaituhi matua:	Lu, Yichen, Friedman, Rachel, Kushner, Nicholas, Doling, Amy, Thomas, Lawrence, Touzjian, Neal, Starnbach, Michael, Lieberman, Judy
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	National Academy of Sciences 2000
Ngā marau:	Biological Sciences
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16664/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10884430/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.14.8027
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