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Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in db/db diabetic mice

Emerging evidence suggests that transforming growth factor-β (TGF-β) is an important mediator of diabetic nephropathy. We showed previously that short-term treatment with a neutralizing monoclonal anti-TGF-β antibody (αT) in streptozotocin-diabetic mice prevents early changes of renal hypertrophy an...

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Autors principals: Ziyadeh, Fuad N., Hoffman, Brenda B., Han, Dong Cheol, Iglesias-de la Cruz, M. Carmen, Hong, Soon Won, Isono, Motohide, Chen, Sheldon, McGowan, Tracy A., Sharma, Kumar
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC16662/
https://ncbi.nlm.nih.gov/pubmed/10859350
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