Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study

BACKGROUND: The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/β-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alterations in TCF7L2 may therefore affect cancer risk...

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Main Authors: Burwinkel, Barbara, Shanmugam, Kalai S, Hemminki, Kari, Meindl, Alfons, Schmutzler, Rita K, Sutter, Christian, Wappenschmidt, Barbara, Kiechle, Marion, Bartram, Claus R, Frank, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665524/
https://ncbi.nlm.nih.gov/pubmed/17109766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-268
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