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Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study
BACKGROUND: The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/β-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alterations in TCF7L2 may therefore affect cancer risk...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1665524/ https://ncbi.nlm.nih.gov/pubmed/17109766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-268 |
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