Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity

Regulatory elements that control tetracycline resistance in Escherichia coli were previously converted into highly specific transcription regulation systems that function in a wide variety of eukaryotic cells. One tetracycline repressor (TetR) mutant gave rise to rtTA, a tetracycline-controlled tran...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Urlinger, Stefanie, Baron, Udo, Thellmann, Marion, Hasan, Mazahir T., Bujard, Hermann, Hillen, Wolfgang
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2000
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16653/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10859354/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.130192197
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