Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells

We have investigated the expression and regulation of the Na(+)–K(+)–2Cl(−) cotransporter (NKCC) by insulin and hyperosmotic stress in L6 rat skeletal muscle cells. NKCC was identified by immunoblotting as a 170 kDa protein in L6 myotubes and mediated 54% of K(+) ((86)Rb(+)) influx based on the sens...

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Bibliographic Details
Main Authors: Zhao, Haiyan, Hyde, Russell, Hundal, Harinder S
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2004
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665208/
https://ncbi.nlm.nih.gov/pubmed/15284343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.066423
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