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Calmodulin kinase is functionally targeted to the action potential plateau for regulation of L-type Ca(2+) current in rabbit cardiomyocytes

L-type Ca(2+) current (I(Ca−L)) triggers Ca(2+) release from the sarcoplasmic reticulum (SR) and both SR and I(Ca−L) are potential sources of intracellular Ca(2+) ([Formula: see text]) for feedback regulation of I(Ca−L). [Formula: see text] bound to calmodulin (Ca(2+)–CaM) can inhibit I(Ca−L), while...

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Autors principals: Wu, Yuejin, Kimbrough, John T, Colbran, Roger J, Anderson, Mark E
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1664743/
https://ncbi.nlm.nih.gov/pubmed/14678498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.053314
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