Estrogen Receptor-Dependent Proteasomal Degradation of the Glucocorticoid Receptor Is Coupled to an Increase in Mdm2 Protein Expression

Glucocorticoids and estrogens regulate a number of vital physiological processes. We developed a model breast cancer cell line, MCF-7 M, to examine potential mechanisms by which the ligand-bound estrogen receptor (ER) regulates glucocorticoid receptor (GR)-mediated transcription. MCF-7 cells, which...

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Hlavní autoři: Kinyamu, H. Karimi, Archer, Trevor K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
Transcriptional Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC166332/
https://ncbi.nlm.nih.gov/pubmed/12897156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.16.5867-5881.2003
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