Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses

Nuclear factor κB (NF-κB) serves to coordinate the transcription of genes in response to diverse environmental stresses. In this report we show that phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2) is fundamental to the process by which many stress signals activate NF-κB. Ph...

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Main Authors: Jiang, Hao-Yuan, Wek, Sheree A., McGrath, Barbara C., Scheuner, Donalyn, Kaufman, Randal J., Cavener, Douglas R., Wek, Ronald C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC166326/
https://ncbi.nlm.nih.gov/pubmed/12897138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.16.5651-5663.2003
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