Alternative Splicing Controls Myotonic Dystrophy Protein Kinase Structure, Enzymatic Activity, and Subcellular Localization

Transcripts of the myotonic dystrophy protein kinase (DMPK) gene, a member of the Rho kinase family, are subject to cell-type specific alternative splicing. An imbalance in the splice isoform profile of DMPK may play a role in the pathogenesis of DM1, a severe multisystemic disorder. Here, we report...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Wansink, Derick G., van Herpen, René E. M. A., Coerwinkel-Driessen, Marga M., Groenen, Patricia J. T. A., Hemmings, Brian A., Wieringa, Bé
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 2003
Sujets:	Cell Growth and Development
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166319/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12897125/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.16.5489-5501.2003
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