Alternative Splicing Controls Myotonic Dystrophy Protein Kinase Structure, Enzymatic Activity, and Subcellular Localization

Transcripts of the myotonic dystrophy protein kinase (DMPK) gene, a member of the Rho kinase family, are subject to cell-type specific alternative splicing. An imbalance in the splice isoform profile of DMPK may play a role in the pathogenesis of DM1, a severe multisystemic disorder. Here, we report...

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Main Authors: Wansink, Derick G., van Herpen, René E. M. A., Coerwinkel-Driessen, Marga M., Groenen, Patricia J. T. A., Hemmings, Brian A., Wieringa, Bé
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC166319/
https://ncbi.nlm.nih.gov/pubmed/12897125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.16.5489-5501.2003
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