A mutant, noninhibitory plasminogen activator inhibitor type 1 decreases matrix accumulation in experimental glomerulonephritis

In fibrotic renal disease, elevated TGF-β and angiotensin II lead to increased plasminogen activator inhibitor type 1 (PAI-1). PAI-1 appears to reduce glomerular mesangial matrix turnover by inhibiting plasminogen activators, thereby decreasing plasmin generation and plasmin-mediated matrix degradat...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Huang, Yufeng, Haraguchi, Masashi, Lawrence, Daniel A., Border, Wayne A., Yu, Ling, Noble, Nancy A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 2003
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166295/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12897205/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI18038
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