Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

The influence of transforming growth factor β (TGF-β) signaling on Neu-induced mammary tumorigenesis and metastasis was examined with transgenic mouse models. We generated mice expressing an activated TGF-β type I receptor or dominant negative TGF-β type II receptor under control of the mouse mammar...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Siegel, Peter M., Shu, Weiping, Cardiff, Robert D., Muller, William J., Massagué, Joan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2003
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166246/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12808151/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0932636100
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