Mouse Vα14i natural killer T cells are resistant to cytokine polarization in vivo

Under different circumstances, natural killer T (NKT) cells can cause a T helper (Th) 1 or a Th2 polarization of immune responses. We show here, however, that mouse NKT cells with an invariant Vα14 rearrangement (Vα14i NKT cells) rapidly produce both IL-4 and IFN-γ, and this pattern could not be alt...

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Autors principals: Matsuda, Jennifer L., Gapin, Laurent, Baron, Jody L., Sidobre, Stéphane, Stetson, Daniel B., Mohrs, Markus, Locksley, Richard M., Kronenberg, Mitchell
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC166240/
https://ncbi.nlm.nih.gov/pubmed/12829795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1332805100
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