Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27(Xic1)
The action of cyclin-dependent kinases (CDKs) is regulated by phosphorylation, cyclin levels, the abundance of CDK inhibitors, and, as recently has been shown for cyclin B/cdc2, their localization. It is unclear how localization regulates the action of cyclin E/Cdk2 and its inhibitors. Here, we show...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
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| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2000
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16624/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10884410/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.14.7796 |
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