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Regulatory CD8(+) T cells fine-tune the myelin basic protein-reactive T cell receptor Vβ repertoire during experimental autoimmune encephalomyelitis

A significant number of self-reactive T cell clones escape thymic negative selection and are released into the periphery, where some are potentially pathogenic. The clonal expansion of self-reactive T cells is known to be limited during initial antigen encounter by apoptotic or anergic mechanisms, r...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Jiang, H., Curran, S., Ruiz-Vazquez, E., Liang, B., Winchester, R., Chess, L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166237/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12824465/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1432871100
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