Inhibiting expression of specific genes in mammalian cells with 5′ end-mutated U1 small nuclear RNAs targeted to terminal exons of pre-mRNA

Reducing or eliminating expression of a given gene is likely to require multiple methods to ensure coverage of all of the genes in a given mammalian cell. We and others [Furth, P. A., Choe, W. T., Rex, J. H., Byrne, J. C., and Baker, C. C. (1994) Mol. Cell. Biol. 14, 5278–5289] have previously shown...

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I whakaputaina i:	Proc Natl Acad Sci U S A
Ngā kaituhi matua:	Fortes, Puri, Cuevas, Yolanda, Guan, Fei, Liu, Peng, Pentlicky, Sara, Jung, Stephen P., Martínez-Chantar, Maria L., Prieto, Jesús, Rowe, David, Gunderson, Samuel I.
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	National Academy of Sciences 2003
Ngā marau:	Biological Sciences
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166217/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12826613/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1332669100
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