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Reduced Release of Pneumolysin by Streptococcus pneumoniae In Vitro and In Vivo after Treatment with Nonbacteriolytic Antibiotics in Comparison to Ceftriaxone

Pneumolysin, a virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities, occurs at concentrations from 0.85 to 180 ng/ml in cerebrospinal fluid (CSF) of meningitis patients. In pneumococcal cultures and in a rabbit meningitis model, the concentrations of pneumolysin...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Spreer, Annette, Kerstan, Holger, Böttcher, Tobias, Gerber, Joachim, Siemer, Alexander, Zysk, Gregor, Mitchell, Timothy J., Eiffert, Helmut, Nau, Roland
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166091/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12878534/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.8.2649-2654.2003
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