Activities of Mutant Prevention Concentration-Targeted Moxifloxacin and Levofloxacin against Streptococcus pneumoniae in an In Vitro Pharmacodynamic Model

The differential effects of moxifloxacin and levofloxacin on the development of resistance in four Streptococcus pneumoniae isolates were examined by using an in vitro pharmacodynamic model. Therapeutic regimens (moxifloxacin: peak, 4.5 μg/ml; half-life [t(1/2)], 12 h; and levofloxacin: peak, 6 μg/m...

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Bibliographic Details
Main Authors: Allen, George P., Kaatz, Glenn W., Rybak, Michael J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC166082/
https://ncbi.nlm.nih.gov/pubmed/12878526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.8.2606-2614.2003
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