Activities of Mutant Prevention Concentration-Targeted Moxifloxacin and Levofloxacin against Streptococcus pneumoniae in an In Vitro Pharmacodynamic Model

The differential effects of moxifloxacin and levofloxacin on the development of resistance in four Streptococcus pneumoniae isolates were examined by using an in vitro pharmacodynamic model. Therapeutic regimens (moxifloxacin: peak, 4.5 μg/ml; half-life [t(1/2)], 12 h; and levofloxacin: peak, 6 μg/m...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Allen, George P., Kaatz, Glenn W., Rybak, Michael J.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2003
Sujets:	Experimental Therapeutics
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166082/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12878526/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.8.2606-2614.2003
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