Biochemical properties of phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotides

Phosphorus-modified phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotides were chemically synthesized and their biochemical properties evaluated. Under physiological pH, these DNA analogs possess negative charge and form stable, complementary A-like DNA:RNA heteroduplexes when analyzed...

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Autors principals: Sheehan, David, Lunstad, Benjamin, Yamada, Christina M., Stell, Brian G., Caruthers, Marvin H., Dellinger, Douglas J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2003
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC165954/
https://ncbi.nlm.nih.gov/pubmed/12853628
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