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Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice

Mice deficient in the epidermal water/glycerol transporter aquaporin-3 (AQP3) have reduced stratum corneum (SC) hydration and skin elasticity, and impaired barrier recovery after SC removal. SC glycerol content is reduced 3-fold in AQP3 null mice, whereas SC structure, protein/lipid composition, and...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hara, Mariko, Verkman, A. S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165880/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12771381/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1230416100
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