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Transcriptional profiling of the Sonic hedgehog response: A critical role for N-myc in proliferation of neuronal precursors

Cerebellar granule cells are the most abundant neurons in the brain, and granule cell precursors (GCPs) are a common target of transformation in the pediatric brain tumor medulloblastoma. Proliferation of GCPs is regulated by the secreted signaling molecule Sonic hedgehog (Shh), but the mechanisms b...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Oliver, Trudy G., Grasfeder, Linda L., Carroll, Audra L., Kaiser, Constanze, Gillingham, Christine L., Lin, Simon M., Wickramasinghe, Rasika, Scott, Matthew P., Wechsler-Reya, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165875/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12777630/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0832317100
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