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IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma

Abstract Medulloblastoma (MB) is the most common pediatric brain malignancy and is divided into four molecularly distinct subgroups: WNT, Sonic Hedgehog (SHHp53mut and SHHp53wt), Group 3, and Group 4. Previous reports suggest that SHH MB features a unique tumor microenvironment compared with other M...

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Hlavní autoři: Haritha Kunhiraman, Leon McSwain, Shubin W. Shahab, Timothy R. Gershon, Tobey J. MacDonald, Anna Marie Kenney
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2023-04-01
Edice:Acta Neuropathologica Communications
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On-line přístup:https://doi.org/10.1186/s40478-023-01557-2
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