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IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma

Abstract Medulloblastoma (MB) is the most common pediatric brain malignancy and is divided into four molecularly distinct subgroups: WNT, Sonic Hedgehog (SHHp53mut and SHHp53wt), Group 3, and Group 4. Previous reports suggest that SHH MB features a unique tumor microenvironment compared with other M...

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Autors principals: Haritha Kunhiraman, Leon McSwain, Shubin W. Shahab, Timothy R. Gershon, Tobey J. MacDonald, Anna Marie Kenney
Format: Artigo
Idioma:Inglês
Publicat: BMC 2023-04-01
Col·lecció:Acta Neuropathologica Communications
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Accés en línia:https://doi.org/10.1186/s40478-023-01557-2
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