Competition between the Rad50 Complex and the Ku Heterodimer Reveals a Role for Exo1 in Processing Double-Strand Breaks but Not Telomeres

The Mre11-Rad50-Nbs1(Xrs2) complex and the Ku70-Ku80 heterodimer are thought to compete with each other for binding to DNA ends. To investigate the mechanism underlying this competition, we analyzed both DNA damage sensitivity and telomere overhangs in Schizosaccharomyces pombe rad50-d, rad50-d pku7...

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Hlavní autoři: Tomita, Kazunori, Matsuura, Akira, Caspari, Thomas, Carr, Antony M., Akamatsu, Yufuko, Iwasaki, Hiroshi, Mizuno, Ken-ichi, Ohta, Kunihiro, Uritani, Masahiro, Ushimaru, Takashi, Yoshinaga, Koichi, Ueno, Masaru
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
DNA Dynamics and Chromosome Structure
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC165728/
https://ncbi.nlm.nih.gov/pubmed/12861005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.15.5186-5197.2003
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