Competition between the Rad50 Complex and the Ku Heterodimer Reveals a Role for Exo1 in Processing Double-Strand Breaks but Not Telomeres

The Mre11-Rad50-Nbs1(Xrs2) complex and the Ku70-Ku80 heterodimer are thought to compete with each other for binding to DNA ends. To investigate the mechanism underlying this competition, we analyzed both DNA damage sensitivity and telomere overhangs in Schizosaccharomyces pombe rad50-d, rad50-d pku7...

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Bibliografiske detaljer
Main Authors: Tomita, Kazunori, Matsuura, Akira, Caspari, Thomas, Carr, Antony M., Akamatsu, Yufuko, Iwasaki, Hiroshi, Mizuno, Ken-ichi, Ohta, Kunihiro, Uritani, Masahiro, Ushimaru, Takashi, Yoshinaga, Koichi, Ueno, Masaru
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC165728/
https://ncbi.nlm.nih.gov/pubmed/12861005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.15.5186-5197.2003
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