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ROCK and Nuclear Factor-κB–dependent Activation of Cyclooxygenase-2 by Rho GTPases: Effects on Tumor Growth and Therapeutic Consequences

Rho GTPases are overexpressed in a variety of human tumors contributing to both tumor proliferation and metastasis. Recently, several studies demonstrate an essential role of transcriptional regulation in Rho GTPases-induced oncogenesis. Herein, we demonstrate that RhoA, Rac1, and Cdc42 promote the...

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Autori principali: Benitah, Salvador Aznar, Valerón, Pilar F., Lacal, Juan Carlos
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC165696/
https://ncbi.nlm.nih.gov/pubmed/12857884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-01-0016
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