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Positive cooperativity between the thrombin and bradykinin B(2) receptors enhances arachidonic acid release

Bradykinin (BK) or kallikreins activate B(2) receptors (R) which couple Gαi and Gαq proteins to release arachidonic acid (AA) and elevate [Ca(2+)](i). Thrombin cleaves the protease-activated-receptor-1 (PAR1) that couples Gα(i), Gα(q) and Gα(12/13) proteins. In CHO cells stably transfected with huma...

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Bibliografske podrobnosti
Main Authors: Hecquet, Claudie, Biyashev, Dauren, Tan, Fulong, Erdös, Ervin G.
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1656694/
https://ncbi.nlm.nih.gov/pubmed/16183725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00868.2005
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