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Positive cooperativity between the thrombin and bradykinin B(2) receptors enhances arachidonic acid release
Bradykinin (BK) or kallikreins activate B(2) receptors (R) which couple Gαi and Gαq proteins to release arachidonic acid (AA) and elevate [Ca(2+)](i). Thrombin cleaves the protease-activated-receptor-1 (PAR1) that couples Gα(i), Gα(q) and Gα(12/13) proteins. In CHO cells stably transfected with huma...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1656694/ https://ncbi.nlm.nih.gov/pubmed/16183725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00868.2005 |
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