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Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes

Ig knock-in mice have been used to study the relative contribution of receptor selection versus clonal selection in the control of autoreactive B cells. The anti-MHC class I 3-83Ig knock-in (3-83Igi) mice manifest extensive receptor editing in the presence of H-2(b). However, receptor editing is als...

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Autores principales: Braun, Uschi, Rajewsky, Klaus, Pelanda, Roberta
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2000
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC16562/
https://ncbi.nlm.nih.gov/pubmed/10829061
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