Imprinted silencing of Slc22a2 and Slc22a3 does not need transcriptional overlap between Igf2r and Air

Silencing of the paternal allele of three imprinted genes (Igf2r, Slc22a2 and Slc22a3) requires cis expression of the Air RNA that overlaps the promoter of one of them (Igf2r). Air is a non-coding RNA whose mode of action is unknown. We tested the role of the Igf2r promoter and the role of transcrip...

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Pubblicato in:	EMBO J
Autori principali:	Sleutels, Frank, Tjon, Grace, Ludwig, Thomas, Barlow, Denise P.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2003
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165611/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12853484/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg341
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