Imprinted silencing of Slc22a2 and Slc22a3 does not need transcriptional overlap between Igf2r and Air

Silencing of the paternal allele of three imprinted genes (Igf2r, Slc22a2 and Slc22a3) requires cis expression of the Air RNA that overlaps the promoter of one of them (Igf2r). Air is a non-coding RNA whose mode of action is unknown. We tested the role of the Igf2r promoter and the role of transcrip...

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Bibliografische Detailangaben

Veröffentlicht in:	EMBO J
Hauptverfasser:	Sleutels, Frank, Tjon, Grace, Ludwig, Thomas, Barlow, Denise P.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2003
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165611/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12853484/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg341
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