v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation

v-Crk induces cellular tyrosine phosphorylation and transformation of chicken embryo fibroblasts (CEF). We studied the molecular mechanism of the v-Crk-induced transformation. Experiments with Src homology (SH)2 and SH3 domain mutants revealed that the induction of tyrosine phosphorylation of cellul...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Akagi, Tsuyoshi, Shishido, Tomoyuki, Murata, Kazutaka, Hanafusa, Hidesaburo
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16538/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10852971/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.140210297
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