Replication of Modified Vaccinia Virus Ankara in Primary Chicken Embryo Fibroblasts Requires Expression of the Interferon Resistance Gene E3L

Highly attenuated modified vaccinia virus Ankara (MVA) serves as a candidate vaccine to immunize against infectious diseases and cancer. MVA was randomly obtained by serial growth in cultures of chicken embryo fibroblasts (CEF), resulting in the loss of substantial genomic information including many...

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Detalhes bibliográficos
Main Authors: Hornemann, Simone, Harlin, Olof, Staib, Caroline, Kisling, Sigrid, Erfle, Volker, Kaspers, Bernd, Häcker, Georg, Sutter, Gerd
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC165266/
https://ncbi.nlm.nih.gov/pubmed/12857909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.15.8394-8407.2003
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