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Toward antibody-catalyzed hydrolysis of organophosphorus poisons

We report here our preliminary results on the use of catalytic antibodies as an approach to neutralizing organophosphorus chemical weapons. A first-generation hapten, methyl-α-hydroxyphosphinate Ha, was designed to mimic the approach of an incoming water molecule for the hydrolysis of exceedingly to...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Vayron, Philippe, Renard, Pierre-Yves, Taran, Frédéric, Créminon, Christophe, Frobert, Yveline, Grassi, Jacques, Mioskowski, Charles
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2000
Teme:
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16498/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10860971/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.13.7058
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