Use of Bmp1/Tll1 Doubly Homozygous Null Mice and Proteomics To Identify and Validate In Vivo Substrates of Bone Morphogenetic Protein 1/Tolloid-Like Metalloproteinases

Bone morphogenetic protein 1 (BMP-1) and mammalian Tolloid (mTLD), two proteinases encoded by Bmp1, provide procollagen C-proteinase (pCP) activity that converts procollagens I to III into the major fibrous components of mammalian extracellular matrix (ECM). Yet, although Bmp1(−/−) mice have aberran...

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Detalles Bibliográficos
Main Authors: Pappano, William N., Steiglitz, Barry M., Scott, Ian C., Keene, Douglas R., Greenspan, Daniel S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC164836/
https://ncbi.nlm.nih.gov/pubmed/12808086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.13.4428-4438.2003
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