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Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellum

Mifepristone (RU486), which binds with high affinity to both progesterone and glucocorticosteroid receptors (PR and GR), is well known for its use in the termination of unwanted pregnancy, but other activities including neuroprotection have been suggested. Cerebellar organotypic cultures from 3 to 7...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Ghoumari, A. M., Dusart, I., El-Etr, M., Tronche, F., Sotelo, C., Schumacher, M., Baulieu, E.-E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164694/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12810951/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1332667100
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