RNA recognition by designed peptide fusion creates "artificial" tRNA synthetase
The genetic code was established through aminoacylations of RNA substrates that emerged as tRNAs. The 20 aminoacyl-tRNA synthetases (one for each amino acid) are ancient proteins, the active-site domain of which catalyzes formation of an aminoacyl adenylate that subsequently reacts with the 3′ end o...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2003
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164610/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12796515/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1332771100 |
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