γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
γ-Secretase catalyzes the intramembrane proteolysis of Notch, β-amyloid precursor protein, and other substrates as part of a new signaling paradigm and as a key step in the pathogenesis of Alzheimer's disease. This unusual protease has eluded identification, though evidence suggests that the preseni...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164455/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12740439/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1037392100 |
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