Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ

The serine/threonine kinase Akt/PKB plays key roles in the regulation of cell growth, survival, and metabolism. It remains unclear, however, whether the functions of individual Akt/PKB isoforms are distinct. To investigate the function of Akt2/PKBβ, mice lacking this isoform were generated. Both mal...

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Detalhes bibliográficos
Main Authors: Garofalo, Robert S., Orena, Stephen J., Rafidi, Kristina, Torchia, Anthony J., Stock, Jeffrey L., Hildebrandt, Audrey L., Coskran, Timothy, Black, Shawn C., Brees, Dominique J., Wicks, Joan R., McNeish, John D., Coleman, Kevin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164287/
https://ncbi.nlm.nih.gov/pubmed/12843127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316885
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