Evidence that the Immediate-Early Gene Product ICP4 Is Necessary for the Genome of the Herpes Simplex Virus Type 1 ICP4 Deletion Mutant Strain d120 To Circularize in Infected Cells

Following infection, the physical state of linear herpes simplex virus (HSV) genomes may change into an “endless” or circular form. In this study, using Southern blot analysis of the HSV genome, we provide evidence that immediate-early protein ICP4 is involved in the process of converting the linear...

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Bibliographische Detailangaben
Hauptverfasser: Su, Ying-Hsiu, Zhang, Xianchao, Wang, Xiaohe, Fraser, Nigel W., Block, Timothy M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1642594/
https://ncbi.nlm.nih.gov/pubmed/16987974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01869-06
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