In Vitro Resistance to the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PA-457 (Bevirimat)

3-O-(3′,3′-dimethylsuccinyl)betulinic acid (PA-457 or bevirimat) potently inhibits human immunodeficiency virus type 1 (HIV-1) maturation by blocking a late step in the Gag processing pathway, specifically the cleavage of SP1 from the C terminus of capsid (CA). To gain insights into the mechanism(s)...

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Detalhes bibliográficos
Main Authors: Adamson, Catherine S., Ablan, Sherimay D., Boeras, Ioana, Goila-Gaur, Ritu, Soheilian, Ferri, Nagashima, Kunio, Li, Feng, Salzwedel, Karl, Sakalian, Michael, Wild, Carl T., Freed, Eric O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1642185/
https://ncbi.nlm.nih.gov/pubmed/16956950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01369-06
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