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Fungicidal mechanism of action of D0870 against Cryptococcus neoformans under acidic conditions.

The fungicidal mechanism of the triazole D0870 against Cryptococcus neoformans under acidic conditions was investigated. D0870 reduced the intracellular K+ content of C. neoformans at pH 4 to about half the value at pH 7 after 12 h of incubation. The 50% inhibitory concentrations of D0870 for ergost...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Principais autores: Yamada, H, Watanabe, T, Kato, K, Mochizuki, H
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1997
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164193/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9420043/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.12.2710
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