Loss of VHL Confers Hypoxia-Inducible Factor (HIF)-Dependent Resistance to Vesicular Stomatitis Virus: Role of HIF in Antiviral Response

Hypoxia-inducible factor (HIF) is a central regulator of cellular responses to hypoxia, and under normal oxygen tension the catalytic α subunit of HIF is targeted for ubiquitin-mediated destruction via the VHL-containing E3 ubiquitin ligase complex. Principally known for its association with oncogen...

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Bibliographic Details
Main Authors: Hwang, Irene I. L., Watson, Ian R., Der, Sandy D., Ohh, Michael
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1641802/
https://ncbi.nlm.nih.gov/pubmed/16928739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01014-06
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