Rotavirus Anti-VP6 Secretory Immunoglobulin A Contributes to Protection via Intracellular Neutralization but Not via Immune Exclusion

Immunoglobulin A (IgA) monoclonal antibodies (MAbs) directed at the conserved inner core protein VP6 of rotavirus, such as the IgA7D9 MAb, provide protective immunity in adult and suckling mice when delivered systemically. While these antibodies do not have traditional in vitro neutralizing activity...

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Bibliografiska uppgifter
Huvudupphovsmän: Corthésy, Blaise, Benureau, Yann, Perrier, Clémentine, Fourgeux, Cynthia, Parez, Nathalie, Greenberg, Harry, Schwartz-Cornil, Isabelle
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2006
Ämnen:
Pathogenesis and Immunity
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1641769/
https://ncbi.nlm.nih.gov/pubmed/16956954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00927-06
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