Rotavirus Anti-VP6 Secretory Immunoglobulin A Contributes to Protection via Intracellular Neutralization but Not via Immune Exclusion

Immunoglobulin A (IgA) monoclonal antibodies (MAbs) directed at the conserved inner core protein VP6 of rotavirus, such as the IgA7D9 MAb, provide protective immunity in adult and suckling mice when delivered systemically. While these antibodies do not have traditional in vitro neutralizing activity...

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Detalhes bibliográficos
Main Authors: Corthésy, Blaise, Benureau, Yann, Perrier, Clémentine, Fourgeux, Cynthia, Parez, Nathalie, Greenberg, Harry, Schwartz-Cornil, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1641769/
https://ncbi.nlm.nih.gov/pubmed/16956954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00927-06
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