Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins.

MICs of DU-6859a, a novel fluoroquinolone, for 18 Klebsiella pneumoniae isolates and 21 Enterobacter cloacae isolates with altered GyrA or altered GyrA and ParC ranged from < or =0.025 to 6.25 microg/ml and from 0.1 to 3.13 microg/ml, respectively. Based on the MICs at which 90% of the isolates were...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Deguchi, T, Yasuda, M, KawamuraT, Nakano, M, Ozeki, S, Kanematsu, E, Nishino, Y, Kawada, Y
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164159/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9371364/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.11.2544
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